New diabetes vaccine research


(stilledlife) #1

This is a new news article just published today that looks very promising. While it won't cure us, it may save the future diabetics.

http://www.garvan.org.au/news-events/news/potential-preventative-therapy-for-type-1-diabetes.html

If anyone has access to diabetes journal online and can get the clinical publication it would be great to see it.

Working with mice that spontaneously develop Type 1 diabetes, Eliana Mariño found that if she blocked BAFF (a hormone that controls survival of B cells) prior to onset, none of the mice developed diabetes.

"This is a remarkable finding, as other B cell depletion methods tested elsewhere have just delayed or reduced disease incidence," said Eliana.

When B cells were depleted, the regulators of the immune system (a subclass of T cells known as T regulatory cells) rose in numbers.

By removing B cells from the picture for a while, it appears you allow T regulatory cells to function as they should, subduing killer T cells and somehow making them tolerant of the insulin producing cells.

The Juvenile Diabetes Research Foundation supported this research. Garvan's Diabetes Vaccine Development Centre (DVDC), the mandate of which is to develop a vaccine for Type 1 Diabetes, is funding further research with the compound.

The molecule used by Grey and colleagues to inhibit BAFF is known as BCMA, and is already being used in clinical trials for other autoimmune diseases, such as Sjogren's Syndrome and Lupus.


(MaDEvans) #2

Thanks for posting this.   Interesting stuff.  :)  It won't help me, but may help my babies one day.


(stilledlife) #3

Well, who knows, In a couple years in joint research with the TB vaccine and the stem cell research this could be a step towards curing the more progressed forms of diabetes.

Anyway, just trying to remain hopeful.


(MaDEvans) #4

[quote user="stilledlife"]

Well, who knows, In a couple years in joint research with the TB vaccine and the stem cell research this could be a step towards curing the more progressed forms of diabetes.

Anyway, just trying to remain hopeful.

[/quote]

Absolutely.  You know what makes me most happy when reading scientific articles (and I read a lot of them, you could probably say I'm obsessed) like these?

"The Juvenile Diabetes Research Foundation supported this research."

We raise money doing those walks, fundraisers, etc all for a reason.


(OmniUser) #5

I read once that the power of the mind has allot of effect on the outcome of things, if we ALL keep a positive outlook, then maybe, just maybe we can find a cure. Weather I belive in that or not, positive is the way to go!